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David Riese's CV

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NCBI MyBibliography

ORCID Profile


Undergraduate Research Fellow

Oak Ridge National Laboratory

Biology Division

RC Mann, JK Selkirk and BK Mansfield, Advisors

BC1.  JK Selkirk, BK Mansfield, DJ Riese II, A Nikbakht, and RC Mann.  "Two-dimensional gel electrophoresis of cytoplasmic proteins in control and transformed 10T1/2 and CVP cells after benzo[a]pyrene treatment."  In: Multilevel health effects research: From Molecules to Man: Proceedings of the Twenty-Seventh Hanford Life Sciences Symposium, JF Park and RA Pelroy, eds.  Batelle Press, Columbus, OH (1988).  ISBN: 09-3547-055-7.

3. JK Selkirk, BK Mansfield, DJ Riese, A Nikbakht, and RC Mann.  Two-dimensional gel electrophoretic comparison of cytoplasmic proteins in C3H10T1/2 cells, a chemically-transformed 10T1/2 line, and a transformation resistant C3H mouse ventral prostate cell line.  Appl Theoret Electrophoresis  2: 43-51 (1991).  PMID: 1932209.

Graduate Student

Yale University School of Medicine

Department of Genetics

Professor Daniel DiMaio, Advisor

1. DJ Riese II, J Settleman, K Neary, and D DiMaio.  Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activity.  J Virology  64: 944-949 (1990).  PMID: 2153255

2. C Leptak, S Ramon y Cajal, R Kulke, BH Horwitz, DJ Riese II, GP Dotto, and D DiMaio.  Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16.  J Virology  65: 7078-7083 (1991).  PMID: 1658398

4. ES Hwang, DJ Riese II, J Settleman, LA Nilson, J Honig, S Flynn, and D DiMaio.  Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene.  J Virology  67: 3720-3729 (1993).  PMID: 8389903

6. DJ Riese II and D DiMaio. An intact PDGF signaling pathway is required for efficient growth transformation of mouse C127 cells by the bovine papillomavirus E5 protein.  Oncogene  10: 1431-1439 (1995).  PMID: 7731695.

BC2.  LA Nilson, LM Petti, D Drummond-Barbosa, DJ Riese II, ES Hwang, T Nottoli, C Henningson Jr, GW Polack, DM Kegler-Ebo, and D DiMaio.  “The role of the cellular platelet-derived growth factor receptor in cell transformation by the bovine papillomavirus E5 protein.”  In: Current Developments in Animal Virology, S Jameel and EK Wagner, eds. Science Publishers (1996).  ISBN: 18-8610-661-4.

Postdoctoral Fellow

Yale University School of Medicine

Department of Pathology

Professor David F. Stern, Advisor

5. DJ Riese II, TM van Raaij, GD Plowman, GC Andrews, and DF Stern.  The cellular response to neuregulins is governed by complex interactions of the erbB receptor family.  Mol Cell Biol 15: 5770-5776 (1995).  PMID: 7565730

7. DJ Riese II, Y Bermingham, TM van Raaij, S Buckley, GD Plowman, and DF Stern.  Betacellulin activates the epidermal growth factor receptor and erbB4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta. Oncogene 12:345-353 (1996).  PMID: 8570211

8. DJ Riese II, ED Kim, K Elenius, S Buckley, M Klagsbrun, GD Plowman, and DF Stern.  The epidermal growth factor receptor couples transforming growth factor alpha, amphiregulin, and heparin-binding EGF-like growth factor to neu, erbB3, and erbB4. J Biol Chem  271: 20047-20052 (1996).  PMID: 8702723.

9. S Kannan, M De Santis, M Lohmeyer, DJ Riese II, GH Smith, N Hynes, M Seno, R Brandt, C Bianco, G Persico, N Kenney, N Normanno, I Martinez-Lacaci, F Ciardiello, DF Stern, WJ Gullick, and D Salomon.  Cripto enhances the tyrosine phosphorylation of shc and activates map-kinase in mammary epithelial cells.  J Biol Chem 272: 3330-3335 (1997). PMID: 9013573.

10. H Chang, DJ Riese II, W Gilbert, DF Stern, and UJ McMahan.  Ligands for erbB family receptors encoded by a newly characterized neuregulin-like gene.   Nature  387: 509-512 (1997). PMID: 9168114

Assistant/Associate Professor

Purdue University College of Pharmacy

Dept. of Medicinal Chemistry & Molecular Pharmacology

Purdue University Center for Cancer Research

11. DJ Riese II and DF Stern.  Specificity within the EGF family/ErbB receptor family signaling network.  Bioessays 20: 41-48 (1998). PMID: 9504046.

12. DJ Riese II, T Komurasaki, GD Plowman, and DF Stern. Activation of ErbB4 by the bifunctional EGF family hormone epiregulin is regulated by ErbB2.   J Biol Chem  273:  11288-11294 (1998). PMID: 9556621.

13. C Sweeney, C Lai, DJ Riese II, AJ Diamonti, LC Cantley, and KL Carraway III. Ligand discrimination in signaling through an ErbB4 receptor homodimer.  J Biol Chem  275: 19803-19807 (2000). PMID: 10867024.

14. F Mu, SL Coffing, DJ Riese II, RL Geahlen, P Verdier-Pinard, E Hamel, J Johnson, and M Cushman.  Design, synthesis, and biological evaluation of a series of Lavendustin A analogs which inhibit EGFR and Lck tyrosine kinases, as well as tubulin polymerization.  J Med Chem  44: 441-452 (2001). PMID: 11462983

15. K Feroz, EE Williams, and DJ Riese II. ErbB2 and ErbB3 do not quantitatively modulate ligand-induced ErbB4 tyrosine phosphorylation.  Cell Signal 14: 793-798 (2002). PMID: 12034361.

16. DJ Penington, I Bryant, and DJ Riese II.  Constitutively active ErbB4 and ErbB2 mutants exhibit distinct biological activities.  Cell Growth Differ 13: 247-256 (2002). PMID: 12114214.

17. SS Hobbs, SL Coffing, ATD Le, EM Cameron, EE Williams, M Andrew, EN Blommel, RP Hammer, H Chang, and DJ Riese II.  Neuregulin isoforms exhibit distinct patterns of ErbB family receptor activation.  Oncogene 21: 8442-8452 (2002). PMID: 12466964.

18. J Walker-Daniels, DJ Riese II, and MS Kinch.  c-Cbl dependent EphA2 protein degradation is induced by ligand binding.  Mol Cancer Res 1: 79-87 (2002). PMID: 12496371.

19. EE Williams, LJ Trout, RM Gallo, SE Pitfield, DJ Penington, I Bryant, and DJ Riese II.  A constitutively-active ErbB4 mutant inhibits drug-resistant colony formation by the DU-145 and PC-3 human prostate tumor cell lines. Cancer Lett 192: 67-74 (2003). PMID: 12637154.

20. SS Hobbs, EM Cameron, RP Hammer, ATD Le, RM Gallo, EN Blommel, SL Coffing, and DJ Riese II.  Five carboxyl-terminal residues of Neuregulin2 are critical for stimulation of signaling by the ErbB4 receptor tyrosine kinase.  Oncogene 23: 883-894 (2004). PMID: 14661053.

21. JL Gilmore and DJ Riese II. secErbB4-26/549 antagonizes ligand-induced ErbB4 tyrosine phosphorylation.  Oncol Res 14: 589-602 (2004). PMID: 15667000.

22.  HF VanBrocklin, JK Lim, SL Coffing, DL Hom, K Negash, MY Ono, SM Hanrahan, SE Taylor, JL Gilmore, I Bryant, and DJ Riese II.  Anilino-dialkoxyquinazolines: Screening epidermal growth factor receptor tyrosine kinase inhibitors for potential tumor imaging probes.  J Med Chem 48: 7445-7456 (2005). PMID: 16279804.

23.  SS Hobbs, RM Gallo, and DJ Riese II.  Phe45 of NRG2beta is critical for the affinity of NRG2beta for ErbB4 and for potent stimulation of ErbB4 signaling by NRG2betaGrowth Factors 23: 273-283 (2005). PMID: 16338790.

24.  JL Gilmore, RM Gallo, and DJ Riese II.  The EGFR-S442F mutant displays increased affinity for Neuregulin2-beta and agonist-independent coupling to downstream signaling events.  Biochem J  396: 79-88 (2006). PMID: 16445385

25.  RM Gallo, I Bryant, R Fry, EE Williams, and DJ Riese II.  Phosphorylation of ErbB4 on Tyr1056 is critical for inhibition of colony formation by prostate tumor cell lines.  Biochem Biophys Res Com 349: 372-382 (2006). PMID: 16934755

26.  SE Pitfield, I Bryant, DJ Penington, G Park, and DJ Riese II.  Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines.  Oncol Res 16: 179-193 (2006). PMID: 17120616

27.  DJ Riese II, RM Gallo, and J Settleman.  Mutational activation of ErbB receptor tyrosine kinases: Insights into mechanisms of signal transduction and tumorigenesis.  Bioessays 29: 558-565 (2007). PMID: 17508401.

28.  N Godin-Heymann, I Bryant, MN Rivera, L Ulkus, DW Bell, DJ Riese II, J Settleman, and DA Haber. Oncogenic activity of EGFR kinase mutant alleles is enhanced by the T790M drug resistance mutation.  Cancer Res 67: 7319-7326 (2007).  PMID: 17671201.

BC3.  RM Gallo and DJ Riese II.  "Activating Mutations of ErbB Family Receptor Tyrosine Kinases."  In: Recent Progress in Cancer Research, C.K. Tang, ed.  Transworld Research Network, Kerala, India (2007).  ISBN: 81-7895-253-X.

29.  JL Gilmore, JA Scott, Z Bouizar, A Robling, SE Pitfield, DJ Riese II, and J Foley.  Amphiregulin-EGFR signaling regulates PTHrP gene expression in breast cancer cells.  Breast Cancer Res Treat 110: 493-505 (2008).  PMID: 17882547

30.  KJ Wilson, CP Mill, EM Cameron, SS Hobbs, RP Hammer, and DJ Riese II.  Interconversion of Neuregulin2 full and partial agonists for ErbB4.  Biochem Biophys Res Com 364: 351-357 (2007).  PMID: 17945187

31.  RM Gallo and DJ Riese II.  The antibody sc-33040-R fails to specifically recognize phosphorylation of ErbB4 on tyrosine 1056.  Growth Factors 25: 329-333 (2007).  PMID: 18236211

32.  T Frogne, RV Benjaminsen, K Sonne-Hansen, BS Sorensen, E Nexo, A-V Laenkholm, LM Rasmussen, DJ Riese II, P de Cremoux, J Stenvang, and AE Lykkesfeldt.  Activation of ErbB3, EGFR, and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant.  Breast Cancer Res Treat 114: 263-275 (2009). PMID: 18409071.

33.  SM Rothenberg, JA Engelman, S Le, DJ Riese II, DA Haber, and J Settleman.  Modeling oncogene addiction with RNA interference.  Proc Natl Acad Sci USA 105: 12480-12484 (2008). PMID: 18711136.

34.  NE Willmarth, A Baillo, ML Dziubinski, K Wilson, DJ Riese II, and SP Ethier.  Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop.  Cell Signal 21: 212-219 (2009).  PMID: 18951974

35.  JA Przybyla, JP Cueva, BR Chemel, KJ Hsu, DJ Riese II, JD McCorvy, JA Chester, DE Nichols, and VJ Watts.  Comparison of the enantiomers of (±)-doxanthrine, a high efficacy full dopamine D1 receptor agonist, and a reversal of enantioselectivity at D1 versus alpha2C adrenergic receptors.  Eur Neuropsychopharmacol 19: 138-146 (2009).  PMID: 19028082

36.  KJ Wilson, JL Gilmore, J Foley, MA Lemmon, and DJ Riese II.  Functional selectivity of EGF Family Peptide Growth Factors: Implications for Cancer.  Pharmacol Ther 122: 1-8 (2009).  PMID: 19135477

37.  CP Mill, JA Chester, and DJ Riese II.  The epidermal growth factor receptor may couple moderate alcohol consumption to increased breast cancer risk.  Breast Cancer – Targets and Therapy (London) 1: 31-38 (2009).  PMID: 20485537

38.  BG Coon, D Mukherjee, CB Hanna, DJ Riese II, M Lowe, and RC Aguilar.  Lowe syndrome patient fibroblasts display Ocr11-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase.  Hum Mol Gen 18: 4478-4491 (2009).  PMID: 19700499.

39.  JL Gilmore, RM Gonterman, K Menon, G Lorch, DJ Riese II, A Robling, and J Foley.  Reconstitution of amphiregulin-EGFR signaling in lung squamous carcinomas activates PTHrP gene expression and cancer-mediated diseases of the bone.  Mol Cancer Res 7: 1714-1728 (2009).  PMID: 19825997 

Gilliland and Franklin Professor

Associate Dean for Research and Graduate Programs

Auburn University Harrison School of Pharmacy

Department of Drug Discovery and Development

40.  J Foley, NK Nickerson, S Nam, KT Allen, JL Gilmore, KP Nephew, and DJ Riese II.  EGFR signaling in breast cancer: Bad to the bone?  Sem Cell Dev Biol 21: 951-960 (2010).  PMID: 20813200.

41.  CP Mill, K Gettinger, and DJ Riese II.  Ligand stimulation of ErbB4 and a constitutively-active ErbB4 mutant result in different biological responses in human pancreatic tumor cell lines.  Exp Cell Res 317: 392-404 (2011).  PMID: 21110957

42.  DJ Riese II.  Ligand-based receptor tyrosine kinase partial agonists: New paradigm for cancer drug discovery?  Expert Opin Drug Disc 6: 185-193 (2011).  PMID: 21532939

43.  MD Zordan, CP Mill, DJ Riese II, and JF Leary.  A high-throughput, interactive imaging, bright-field wound healing assay.  Cytometry A 79A: 227-232 (2011). PMID: 22045642.

BC4.  NK Nickerson, JL Gilmore, KT Allen, DJ Riese II, KP Nephew and J Foley. "EGFR Ligand-Specific Signaling in Breast Cancer Metastasis: Recurring Developmental Themes." Breast Cancer – Carcinogenesis, Cell Growth, and Signalling Pathways, Mehmet Gunduz and Esra Gunduz, eds.  Intech Publishing, Rijeka, Croatia (2011).  ISBN: 978-953-307-714-7.

44.  CP Mill, MD Zordan, SM Rothenberg, J Settleman, JF Leary, and DJ Riese II.  ErbB2 is necessary for ErbB4 ligands to stimulate oncogenic activities in models of human breast cancer.  Genes & Cancer 2: 792-804 (2011). PMID: 22393464.

45.  KJ Wilson, CP Mill, S Lambert, J Buchman, TR Wilson, V Hernandez-Gordillo, RM Gallo, LMC Ades, J Settleman, and DJ Riese II.  EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. Growth Factors  30: 107-116 (2012).  PMID: 22260327.

46.  KJ Wilson, CP Mill, RM Gallo, EM Cameron, H VanBrocklin, J Settleman, and DJ Riese II.  The Q43L mutant of neuregulin 2beta is a pan-ErbB receptor antagonist.  Biochem J  443: 133-144 (2012).  PMID: 22216880.

47.  J Foley, NK Nickerson, DJ Riese, PC Hollenhorst, G. Lorch, AM Foley.  At the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of the bone.  Odontology 100: 109-129 (2012).  PMID: 22684584.

48.  NK Nickerson, CP Mill, HJ Wu, DJ Riese II, and J Foley.  Autocrine-derived epidermal growth factor receptor ligands contribute to recruitment of tumor-associated macrophage and growth of basal breast cancer cells in vivo.  Oncol Res 20:303-17 (2013).  PMID: 23879171.

49.  RE Allen, J Copeland, AS Franks, R Karimi, M McCollum, DJ Riese II, and AYF Lin. Team-based learning in US colleges and schools of pharmacy. Am J Pharm Ed 77 (06): 115 (2013).  PMID: 23966718.

50.  RM Gallo, IN Bryant, CP Mill, S Kaverman, and DJ Riese 2nd.  Multiple functional motifs are required for the tumor suppressor activity of a constitutively-active ErbB4 mutant.  J Cancer Res Ther Oncol 1 (01): 104 (2013). PMID: 24791013.  Full Text.

51.  DJ Riese II and RL Cullum.  Epiregulin: Roles in Normal Physiology and Cancer.  Sem Cell Dev Biol  28 (01): 49-56 (2014). PMID: 24631357.

52.  S Kanthala, CP Mill, DJ Riese II, M Jaiswal, and S Jois.   Expression and purification of HER2 extracellular domain proteins in Schneider2 insect cells.  Protein Expr Purif  125 (01): 26-33 (2016). PMID: 26363121

53.  FML Kabir, P DeInnocentes, P Agarwal, CP Mill, DJ Riese II, and RC Bird.  Estrogen Receptor-alpha, Progesterone Receptor and c-erbB/HER-Family Receptor mRNA Detection and Phenotype Analysis in Spontaneous Canine Models of Breast Cancer.  J Vet Sci 18 (02) 149-158 (2017).  PMID: 27515268.